Senior Investigator
National Cancer Institute
Royal Institute of Technology, Sweden
Frederick, Maryland, United States
Hans started his scientific career using a 300,000-volt helium-cooled electron microscope (EM) to image biological molecules operating as “machines” inside cells. He quickly realized that available computational methods were limiting progress and started to write his own specialized computer code to transform 2D EM images into 3D structures.
As a postdoctoral fellow at Stanford University, his theoretical work grew into the first version of the open-source program package SIMPLE. In 2014 he established his independent group at the Biomedicine Discovery Institute, Monash University, Australia. At Monash, he developed game-changing new technologies for 3D structure determination and time-series analysis of movies obtained with aberration-corrected transmission electron microscopy and developed algorithms allowing 3D reconstruction at near-atomic resolution in a matter of hours, using standard desktop computers. He was recruited as a Senior Investigator at NIH/CCR/NCI-Frederick in October 2021.
Hans’ vision is to develop software that has the potential to accelerate discovery across multiple disciplines and make a significant impact on biomedical research world-wide. The tools available in the SIMPLE/SINGLE software packages that he created and leads the development of will facilitate drug development and allow characterization of the atomic structure of nanocrystals.
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Tuesday, July 25, 2023
11:15 AM – 11:45 AM US CST